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No specific studies have been conducted with ibuprofen lysine.
Whilst no teratogenic effects have been demonstrated with ibuprofen acid in animal experiments, the use of ibuprofen during pregnancy should, if possible, be avoided during the first 6 months of pregnancy. It should not be used for the last trimester of pregnancy as there is a risk of premature closure of the foetal ductus arteriosus with possible persistent pulmonary hypertension. The onset of labour may be delayed and duration increased with an increased bleeding tendency in both mother and child (see Contraindications). In limited studies, ibuprofen appears in the breast milk in very low concentration and is unlikely to affect the breat-fed infant adversely (see Impaired Female Fertility under Precautions).
